The Audiological Follow-Up of Children with Symptomatic Congenital Cytomegalovirus Infection: An Experience in Two Italian Centers

Background: Congenital cytomegalovirus (cCMV) infection is the leading cause of non-hereditary sensorineural hearing loss in children. While about 10% children reportedly display symptoms at birth, 85–90% cCMV cases are asymptomatic. However, 10–15% these asymptomatic infants may later develop hearing, visual, or neurodevelopmental impairments. This study aimed to evaluate impact on newborns’ function with a particular emphasis progressive and late-onset cases. Methods: retrospective chart analysis longitudinal character was conducted two Italian centers: Center 1 (from November 2007 31 December 2021) 2 January 2012 2021). Data collected included newborn screening results, characterization (unilateral/bilateral, degree impairment), audiological follow-up. Results: The cohort consisted 103 (42% males, 58% females). In total, 28 presented impairment; 71.4% (20 out 28) were severe/profound, 35.7% due unilateral loss. Out twenty-eight, six experienced progression four had Conclusions: absence universal screening, birth for remains critical factor early diagnosis. A significant percentage affected by normal evaluations easily lost Close collaboration between neonatologists, pediatricians, services fundamental ensure timely diagnosis treatment cCMV-related